Ubiquinol - Powerful Antioxidant

What is Ubiquinol? 

Ubiquinol is the reduced form of Coenzyme Q10 (CoQ10). CoQ10 is a natural nutrient that’s found in the mitochondria (the energy producing center of the cell). It is called a “coenzyme” because of its unique ability to participate in chemical reactions and remain unchanged. CoQ10 assists in two vital cellular activities: ATP production (adenosine triphosphate, the energy-rich compound that fuels the body’s activities) and free radical scavenging.*1 To carry out these activities, mitochondrial CoQ10 continuously cycles from ubiquinone, its ATP production state, to ubiquinol, its antioxidant free radical scavenging state.*2 

While free radical formation is harmful to all cells, it is especially dangerous to cells with high biologic activity, such as heart and brain cells.* The highest concentration of CoQ10 is found in cardiovascular (heart) and nervous system (brain) cells to protect their vital functions.*3,2 Ubiquinol is an important antioxidant because it is present at sites where free radicals inflict significant damage.*8,5,6 

Is Ubiquinol a Better Form of CoQ10? 

Ubiquinol is a different form of CoQ10 and serves a very different purpose. CoQ10 is used to make energy, while ubiquinol is a powerful antioxidant that protects the cell and cell membrane, including the energy-producing mitochondria, from the damaging effects of free radicals. Ubiquinol also helps in recycling vitamin E and C, which keeps them active as antioxidants. 

Most healthy adults in their 20s and 30s can easily metabolize CoQ10 and convert it into ubiquinol; thus, supplementing with regular CoQ10 will likely be the most efficient way to raise ubiquinol levels.* For individuals who are 40+ or looking for additional support, ubquinol is more beneficial since the body’s ability to produce CoQ10 and convert it into ubiquinol is diminished. 

Studies suggest that ubiquinol is much more effective than the energy-producing CoQ10 in patients with congestive heart failure, high LDL (bad cholesterol), and in older adults. Both forms of CoQ10 have anti-inflammatory properties. 

Scientific Research 

In an experiment which used an animal model of aging, ubiquinol supplementation was associated with healthier aging (as determined by skin, eye, skeletal and general health) in comparison to aging in both the CoQ10 and control group.*7 The control group in this experiment experienced double the senescence (biological aging) scores in mid-life when compared to the ubiquinol group, while the CoQ10 supplemented group had senescence scores approximately 1.5 times as high as the ubiquinol group.* Increased senescence scores are an indication of the signs of aging.* 

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Medicine-Plants.com

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 

References 

1. Barry R. The Power of Kaneka QH: The Key to Energy, Vitality, and a Healthy Heart. Sherman Oaks, CA: Health Point Press; 2008: 1-48. 

2. Coenzyme Q10. Monograph. Altern Med Rev 2007;12:159-68 

3. Guyton AC, Hall JE. Mitochondria. In: Textbook of Medical Physiology. 9th ed. Philadelphia, Pa: WB Saunders; 2001:16-17. 

4. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007;37:31-7. 

5. Crane F, Hatefi Y, Lester R, Widmer C. Isolation of a quinone from beef heart mitochondria. Biochim Biophys Acta 1957;25: 220-1. 

6. Morton RA. Ubiquinone. Nature 1958;182:1764-7. 

7. Unpublished data. Kaneka Corporation. October 22, 2003. 

8. Ruiz-Jiménez J, Priego-Capote F, Mata-Granados JM, Quesada JM, Luque de Castro MD. Determination of the ubiquinol-10 and ubiquinone-10 (coenzyme Q10) in human serum by liquid chromatography tandem mass spectrometry to evaluate the oxidative stress. J Chromatogr A 2007;1175:242-8. 

Osteopenia - Should You Be Concerned?

You’ve got osteopenia. If you’ve heard these words from your doctor, your first response may have been fear. The perceived connection to osteoporosis may have increased your anxiety. Likely, your doctor told you that osteopenia is not necessarily serious, but that it can be an indication that you are on the fast track to osteoporosis. While you’re reeling from the fear of multiple fractures and future hip surgery, your doctor proceeds to ease your fear with a prescription for a drug to ward off this terrifying disease. Before you fill that prescription, do your research! Osteopenia may not be as bad as it sounds. 

What is Osteopenia? 

Simply put, osteopenia is a gradual loss of bone mineral density. Its presence may indicate that the loss of bone density has begun to outpace the natural formation of bone. However, you could just be one of many who never developed a high peak bone mass in your youth, and may not be currently losing bone mass at all. Whatever the case, osteopenia is a natural part of the aging process for most of us. 

If this is the first time you’ve heard of this condition, you’re not alone. The name is less than 20 years old - coined in 1992 by researchers for the World Health Organization. Interestingly, some suggest that osteopenia is an invented disease. “In fact, little more than a decade ago, it didn’t even exist… It’s another situation in which a bunch of experts got together, set some arbitrary guidelines, and bingo! Millions of people who were healthy the day before woke up with a disease.” Dr. Julian Whitaker, Whitaker Wellness Institute, CA. 

The word “osteopenia” literally means “bone poverty”. This fear-inspiring term quickly opened the door for big pharmaceutical companies to capitalize on what they suggest is a “dangerous disorder,” substantially increasing their profits from the sale of Fosomax, Actonel, Boniva, Evista, and other drugs, all claiming to prevent or treat bone loss. Your doctor may have prescribed one of these for you, believing the effective marketing campaigns of the makers of these drugs. 

Don’t be too quick to jump on the “dangerous disorder - got to take the drugs bandwagon”. Remember that just about everyone will experience some level of bone density loss as they age. After all, it is a natural part of the aging process. In reality, you can have osteopenia and still have perfectly healthy bones. They may not be as dense as they were when you were 30 years old, but they may still be healthy. 

MACA750™ is especially high in calcium and magnesium and has proven to be successful in promoting healthy bone formation. It is therefore an herb of great benefit to those with osteoporosis or those at risk of osteoporosis. 

You might also find this of interest: 

Be well, 

Medicine-Plants 

Low Libido/Erectile Dysfunction

Nearly half of the male population by age 50 experience lethargy, decreased libido, depression, irritability and mood swings, hot flashes, insomnia, weakness, loss of bone mass and muscle tone, and erectile dysfunction/impotence. It has long been called male menopause or andropause. 

One study showed 51% of normal, healthy males aged 40 - 70 experience some degree of impotence. This is not due to the aging process alone, since 40% of males remain sexually active at 70 plus years. A major contributing factor can be linked to physical problems, such as heart disease, atherosclerosis, hypertension, diabetes, smoking, certain prescription and non-prescription medications, chronic disease, excessive alcohol consumption, poor diet, lack of exercise, and even obesity. Or it may be psychological - depression, anxiety, other mental health problems, relationship problems, fatigue, and stress. However, it is often a combination of the physical and psychological that causes these symptoms, and the best solution will take all of this into consideration. 

Suffering in Silence 

Despite the prevalence of commercials for Viagra® and Cialis®, many men continue to suffer in silence, which only exacerbates their problem. Some are embarrassed by these commercials; feeling they are advertising their problem to the world, when they don’t even want to talk about it with their mates, much less their doctor. Others are concerned about the potentially dangerous side-effects of these drugs. 

With all these legitimate concerns is there a safe natural way to deal with the symptoms of male menopause? Yes. MACA750™ is proving highly successful in managing the symptoms of male menopause, including erectile dysfunction. 

Medical Doctors Recognize Male Menopause 

“Male Menopause” was first described in the United States sixty years ago in the Journal of the American Medical Association (JAMA, 1938, 112:1441). Dr. August Werner gave an accurate account of the experience. Six years later, another JAMA article provided evidence that this “male menopause” was a true hormone deficiency due to low testosterone. Blind controlled studies showed how the symptoms responded to testosterone but not to placebo injections. In l944, two American doctors, Dr. Carl Heller and Dr. Gordon Myers, did a blind controlled trial showing the effectiveness of testosterone treatment. Yet fear of side effects from testosterone, especially prostate cancer caused this form of therapy to lose popularity. 

Doctors are once again identifying male menopause with the decline of hormones. “Mid-Life Crisis” is now being identified also as “Male Menopause.” In spite of this men are still tight-lipped about these very personal symptoms. 

MACA750™ has proven very effective for both male and female menopause and is being used by both alternative health practitioners and medical doctors. MACA750™ has been shown to raise hormone levels in men, as well as women. Because of the adaptogenic qualities of MACA750™, hormone levels that drop off suddenly become balanced, relieving the uncomfortable hot flashes, night sweats, fatigue and loss of libido, and sexual problems that so many men experience. 

Herbs vs. Drugs on the Libido Issue - What the Consumer Can Expect. 

Drugs act fast. A drug like Viagra® may work within an hour or so. Herbs feed and nourish our bodies and this is a time consuming process yet a healthy one. We can’t expect herbs and other natural supplements to compete time-wise with drugs. Herbs work slowly. This is important to remember when treating any condition with herbs, but especially sexual dysfunction. So be patient.

For additional information see: 

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Medicine-Plants.com
Orotates and The Mineral Transporters of Dr. Nieper

Orotates and The Mineral Transporters of Dr. Nieper

What’s the best way to take mineral supplements? Picolinates? Amino acid chelates? Chelates involving other organic acids such as citrates? Whenever anyone asks my opinion on such matters, I find myself giving an answer they often don’t expect: “Try orotates!” The blank looks I usually get in response tell me that most people need some educating on the subject, hence this article.

Orotates are the mineral salts of orotic acid, a natural substance found in our bodies and also in various foods including dairy products. As theorized many years ago by the pioneering German physician Hans Nieper, orotates are a component of a natural system of electrolyte carriers for distributing minerals throughout the body. [1] (A different compartment of this same system uses amino acid complexes such as aspartates and arginates to deliver minerals.) Based on his observations of cells in culture, Nieper concluded that molecules of calcium orotate and magnesium orotate can pass through cell membranes intact without “dissociating” or breaking apart into their component ions, and thereafter release their respective ions only at specific membrane sites within the cell. [2] Subsequently he extended this principle to include other orotates such as lithium and zinc.

Working at his clinic in Hannover, Germany, Nieper applied his unique discoveries to the treatment of diseases such as cancer, heart disease, multiple sclerosis, and rheumatoid arthritis as well as other autoimmune conditions. Over the course of more than four decades Dr. Nieper treated thousands of patients with his innovative mineral transporters, many apparently with great success. However, in later years he published relatively little in medical journals, preferring instead to reserve his time for treating patients and for presenting occasional seminars about his work to medical professionals and consumers. As a result, his discoveries have been considered controversial by mainstream medicine or simply ignored, at least until recently.

Hans Nieper died in October, 1998 at the age of 70-ironically just at a time when many of his ideas had finally begun gaining wider acceptance. Only a few weeks before his death, in fact, the collected papers from a symposium on the medical uses of magnesium orotate were published in the journal Cardiovascular Drugs and Therapy. Overall, the symposium lent credence to Nieper’s claims for the cardiovascular benefits of magnesium orotate while calling for additional human trials. [3]

How do the orotates work?
That’s a complex question necessitating a somewhat detailed discussion of biochemistry and for this reason my explanation has been relegated to an article of its own. See How Orotates Work. For now I’ll just state my summary conclusions: There is independent scientific evidence corroborating Nieper’s theory of orotates as mineral transporters. In my judgment, the evidence tends to support Nieper’s criteria for orotate as an electrolyte carrier, namely, (1) a low dissociation constant, (2) an affinity for specific cellular systems or organs, and (3) a metabolic pathway which liberates the transported mineral within the targeted organ or system. [1]

Perhaps the recent wave of interest in Dr. Nieper’s compounds will inspire further research on the mechanism of transport. Until then there’s plenty of evidence for the validity of Dr. Nieper’s ideas in previous publications by Nieper and other researchers. The following sections summarize these results on the medical and biological effects of the various mineral orotates, together with a brief discussion of other potential uses. Beyond that, there is direct and compelling evidence from personal experience-see my article Orotates for Weight Loss, Cognitive Enhancement, and Athletic Performance for details. To give but one example, there can be little doubt about the effectiveness of Nieper’s products when the majority of people trying calcium orotate as an appetite suppressant can tell almost immediately that it works, just as Nieper said it would.

Magnesium orotate
Of all the macronutrient minerals in the human body, magnesium is the one most likely to be deficient. Magnesium deficiency has been linked to a large number of disorders, including diabetes [4], hypertension [5], dementia [6], and osteoporosis. [7] Magnesium compounds are medically accepted as helpful for treating migraines, asthma, chronic lung disease, and cardiac conditions such as heart attack and arrhythmias. [8] Magnesium orotate should be even more effective than other magnesium supplements for such conditions, in view of its enhancement of magnesium transport and its documented benefits [3] [9] [10] in cardiovascular disorders.

In addition to its cholesterol-lowering and heart-energizing effects, magnesium orotate has also been reported to improve the elasticity of blood vessels. [11] Using capillarographic recordings Dr. Nieper was able to show that a daily dose of 380 mg magnesium orotate over 15 months was sufficient to normalize or greatly improve the elasticity of peripheral blood vessels in 60 of 64 patients. Such an effect on vessel elasticity suggests the use of magnesium orotate for lowering blood pressure as well as for inhibiting arteriosclerosis.

Dr. Nieper generally combined magnesium orotate with other nutrients for optimal effect. For example, it’s known that potassium deficiency is closely linked with magnesium deficiency because magnesium ions are needed to activate an important cellular pump which regulates sodium and potassium levels. [4] [5] In addition, potassium orotate itself is thought to be beneficial for conditions such as cardiomyopathy and congestive heart failure (see section below on Potassium orotate). So it’s not surprising to find that Nieper recommended a combination of magnesium orotate (1.5 to 2.5 grams per day) plus potassium orotate (138 to 300 mg daily) for treating angina and coronary heart disease. [12] He also suggested adding the pineapple enzyme bromelain (120 to 140 mg per day) to inhibit platelet aggregation and dissolve fibrin clots. The 2- and 4-year mortality rates for patients on this regimen were reportedly reduced by 90% or more compared to patients in other studies who received conventional medications. [12]

A similar Nieper combination designed for unclogging arteries involved magnesium orotate (1 to 1.5 grams per day) together with carnitine (4 grams per day), selenium (Se-enriched yeast, 300 to 400 mcg per day), bromelain (240 mg daily), and the enzyme serrapeptase 10 to 15 mg per day). See my article on CardioPeptase for additional information.

Finally, it’s worth pointing out that magnesium orotate isn’t just for heart patients-it’s also for healthy athletes. In a double-blind, randomized study, [23] competitive triathletes were studied after 4 weeks of supplementation with placebo or magnesium orotate. [13] Blood was collected before and after a test consisting of a 380-meter swim, a 20-km bicycle race, and a 5-km run. Compared to placebo, magnesium orotate caused a greater increase during the test in serum glucose and venous partial pressure of oxygen, and a greater decrease in serum insulin, blood acidity, and serum cortisol. The changes in glucose use and reduction in stress responses occurred without affecting the athletes’ competitive potential-quite the reverse, in fact. The exercising athletes had greater endurance as a result of the magnesium orotate supplements. By contrast, a different study in which athletes were supplemented with magnesium oxide (which is relatively poorly absorbed) reported no improvement in exercise performance, attesting to the superior uptake of magnesium in the orotate form compared to the oxide. [14]

Potassium orotate
Potassium deficiency is not considered to be common in view of the availability of adequate amounts of this mineral in most diets. Nevertheless, potassium deficiency is known to arise as a secondary consequence of magnesium deficiency. [5] Another cause of deficiency is the use of potassium-wasting diuretics to control high blood pressure. [15] Disease states known to be associated with low serum or tissue potassium include diabetes [4], insulin resistance [16], and high blood pressure [5] [17] as well as rheumatoid arthritis [18] and heart disease. [18]

Dr. Nieper’s original motivation to develop orotic acid as an electrolyte carrier was inspired by results due to E. Bajusz showing that potassium orotate can prevent idiopathic myocardial necrosis in hamsters, while potassium chloride is ineffective. [19] [20] Nieper subsequently found that potassium orotate was highly effective for alleviating human cardiovascular diseases when combined with magnesium orotate (see discussion in the section below on Magnesium orotate). Even when administered by itself to heart attack patients, potassium orotate has been reported to result in faster recovery of myocardial contractibility than in placebo-treated controls. [21]

Other reported applications for potassium orotate include acceleration of wound healing [22] and enhancement of recovery and immune function following surgery. [23] Although not an antioxidant itself, potassium orotate facilitates the tissue uptake of vitamin C from serum and increases blood levels of reduced glutathione. [24] Finally, studies in animals have revealed antidepressant, psychostimulant, and anxiety-reducing effects associated with chronic potassium orotate administration. [25] [26]

Lithium orotate
Although no absolute need for lithium has yet been established in human nutrition, lithium intake can affect many different systems in the body in a positive way. Lithium is most famous for treatment of manic-depressive disorders. At high doses lithium can depress dopamine release [27] (which tends to flatten elevated moods), while at lower doses it can stimulate serotonin synthesis [28] (which gives an antidepressant effect). Although most people don’t need treatment for manic-depressive illness, a very large number with mild depression could benefit from low-dose lithium supplements. Recently it’s been discovered that lithium has potent neuroprotective effects as well (see the article Lithium increases gray matter in the brain). The hope now is that lithium supplements will prove capable of halting the progress of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis, among others.

Lithium is also known for its immune-enhancing and antiviral effects, especially against herpes simplex virus. [29] It may be equally effective against measles, judging by results obtained in vitro. [30] The downside to lithium’s immune-stimulating activity is that it can also set off autoimmune reactions in susceptible individuals. [31] For this reason, if you suffer from an existing autoimmune disease such as rheumatoid arthritis or lupus, don’t take lithium supplements without first consulting your health care professional.

Another benefit of supplementing with lithium is its insulin-sensitizing effect. [32] Lithium has been found to decrease blood glucose levels, especially when used in conjunction with insulin or oral glucose-lowering drugs. [33] Results such as these have led to suggestions that lithium might be useful in treating diabetes. [32] [33]

As expected in view of the neurological activity of lithium compounds, Dr. Nieper found that lithium orotate in doses of 138 mg 4 to 6 times per week was effective in treating cases of depression, headaches and migraine, epilepsy, and even alcoholism. [34] The amount of lithium contained in the doses was only a small fraction of the amount conventionally given as therapy for manic-depressive illness, thus avoiding the risk of kidney toxicity typically associated with high-dose lithium. Elsewhere Dr. Nieper reported that 5 mg of lithium in the form of orotate was roughly as effective as 100 mg of lithium in the form of carbonate, giving a 20-fold enhancement of potency thanks to efficient transport of the lithium by its orotate carrier. [35]

Nieper’s results were subsequently confirmed in a group of 42 alcoholic patients who were followed for between 6 months and 10 years. [36] Treatment with 138 mg of lithium orotate per day resulted not only in a marked decline in alcoholic relapses, but also in improvements in liver, cardiovascular, thyroid, and immune function. Migraines, cluster headaches, manic behavior, and seizure disorders were also reduced among this group. Eight patients reportedly developed muscle weakness, loss of appetite, and mild apathy as a result of treatment, but symptoms disappeared after the dose was reduced to 138 mg 4 to 5 times per week. The improvements in liver function appeared to be due to a synergy between lithium orotate and calcium orotate, both of which were administered to the alcoholic patients with liver disease. For more information on the treatment of liver disorders with a combination of lithium and calcium orotate, see the section below on Calcium orotate.

Note on lithium safety
As mentioned above, lithium in large doses can be toxic, especially to the kidneys. The therapeutic dose of lithium when administered as lithium carbonate is close to the toxic dose (i.e., there is a narrow therapeutic window), and for this reason blood levels and organ function need to be monitored continually. This is true only for lithium carbonate and not for lithium orotate. For example, according to the Physicians’ Desk Reference, the recommended dose of lithium carbonate administered for treatment of psychiatric disorders is 300 mg three to four times per day. Since each 300 mg tablet of lithium carbonate provides 56.8 mg of elemental lithium, the total amount of lithium delivered would range from 170.4 mg to 225.6 mg per day. By contrast one lithium orotate tablet delivers 5.8 mg elemental lithium, which is roughly 1/30 to 1/40 the amount delivered by the recommended daily dose of lithium carbonate. Even taking several lithium orotate tablets per day would amount to a dose well below the toxic level for lithium.

Similarly, consumers of lithium carbonate are often warned of possible toxic effects if other medications such as ACE inhibitors or diuretics are taken concurrently. Although these warnings appear to be true for pharmaceutical lithium compounds only and not for modest doses of lithium orotate, it would nevertheless be wise to consult with a health care professional for anyone contemplating taking lithium orotate concurrently with either of these medications.

Zinc orotate
Zinc deficiency has been implicated in age-related osteoporosis [37] and, conversely, zinc supplements can speed the healing of fractures in animal models. [38] Zinc also plays a vital role in immune function, where deficiency is associated with atrophy of the thymus, reduction in white blood cell counts, and increased susceptibility to infection. [39] [40] Another important role for zinc is in maintaining male reproductive function. Deficiency of zinc is associated with hypogonadism and low levels of serum testosterone, reversible upon supplementation. [41] Zinc also appears to be important for the activity of growth hormone (GH) since GH loses effectiveness under conditions of zinc deficiency. [42]

As is well known, one of the major roles for zinc in human nutrition is its antioxidant activity. [43] Increasing zinc intake may protect against conditions associated with both oxidant stress and zinc deficiency, such as diabetes. [44] Zinc deficiency is known to be associated with an increased prevalence of coronary artery disease as well as diabetes, and with several associated risk factors including hypertension, hypertriglyceridemia, and insulin resistance (syndrome X). [45] [46]

In view of the association of zinc deficiency with diabetes, it’s not surprising to learn that zinc orotate stabilizes blood glucose and reduces the need for insulin in diabetics, according to Dr. Nieper. [35] In addition, zinc orotate and other zinc compounds synergize with sulfur-containing antioxidants (sulfhydryls) to protect against free radical-induced tissue injury, [43] [47] a result which may have relevance to the treatment of diabetes as well as other diseases of increased oxidative stress. [44]

Calcium orotate
Treatment or prevention of osteoporosis is one of the main applications for calcium supplements generally and for calcium orotate in particular. Dr. Nieper specifically cited its effectiveness in treating both inflammatory and osteoporotic decalcification and in relieving pain resulting from osteoporosis of the spine. [19] In another paper Nieper reported successful recalcification of malignant bone tumors (thereby preventing further metastases) with calcium orotate in 10 out of 13 subjects. [1] He also found that a daily oral dose of about 600 mg was sufficient to reverse bone loss caused by radiological therapy in cancer patients, an effect documented by X-ray photos of several subjects before and after treatment with calcium orotate. [1] [19] A further paper reported on the benefits of calcium orotate in treating joint diseases such as arthritis and spondylitis. [48] On the basis of results such as these, it seems likely that calcium orotate can also have a beneficial impact on the degenerative bone changes characteristic of osteoarthritis. (For information on an orotate formulation optimized for bone health, see description below of Osteo Forte Orotate.)

But calcium orotate has many other uses as well. In his remarkable paper of 1969 Dr. Nieper reported his observations after dispensing more than 38,000 doses of calcium orotate to a large number of patients over the course of a year. [19] Nieper found that low-dose calcium orotate was effective in treating severe refractory psoriasis, lowering blood pressure in cases of arteritis and arteriosclerosis, relieving angina pectoris, and ameliorating cases of multiple sclerosis, disseminated encephalitis, retinitis, chronic hepatitis, and colitis. The dosages employed varied from about 300 to 1000 mg calcium orotate per day. No side effects were noted except for a loss of appetite among obese chronic overeaters, some of whom were able to lose a substantial amount of excess weight.

In subsequent research Nieper reported achieving complete remissions of chronic, aggressive hepatitis in 14 patients treated with 3 grams of calcium orotate per day for 2 years; 4 of these patients also required cortisone therapy, although at a decreased dosage. [49] Nieper found that an optimal therapeutic effect was achieved after a period of 9 to 18 months of daily supplementation, but not earlier. However, with a regimen of 2 grams calcium orotate plus 138 mg lithium orotate per day, the same beneficial results could be achieved in cases of hepatitis and cirrhosis in only 2 to 3 months. This research should be re-investigated in view of the emerging global health crisis of hepatitis C.

Around 1975 Dr. Nieper began treating lupus erythematosus patients with calcium orotate. [35] He found that a dose of 1 to 2.5 grams was surprisingly effective when administered over a period of at least one year, even in advanced cases with pulmonary constriction, pleural effusions, or cardiomyopathy. [35] [50] Therapy also involved low-dose prednisone and a variety of nutrients to promote adrenal steroid synthesis, such as selenium and vitamins C and D2, as well as other calcium and magnesium salts. An account of one patient’s successful response to therapy with calcium orotate and other Nieper compounds can be found in an article available from the Brewer Science Library. [51] In addition Nieper found that multiple sclerosis sometimes accompanies lupus, so it’s not surprising that his protocol for treating MS is strikingly similar to that for treating lupus. [52] [53] He recommended a dose of 1 gram calcium orotate per day for MS patients, with a higher dose given to those patients with a tendency toward migraine-like headaches.


Be well,
Medicine-Plants


Health Disclaimer! The information presented on this site should not be construed as personal medical advice or instruction. You should consult appropriate health professionals on any matter relating to your health and well-being. The information and opinions provided here are believed to be accurate and sound, based on the best judgment available to the authors, but readers who fail to consult appropriate health authorities assume the risk of any injuries. The publisher is not responsible for errors or omissions.

References
1. Nieper HA. Recalcification of bone metastases by calcium diorotate. Agressologie. 1970;11(6):495-502. Available as article #CA21 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
2. Nieper HA. The clinical applications of lithium orotate. A two years study. Agressologie. 1973;14(6):407-11. Available as article #CM12 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
3. Rosenfeldt FL. Metabolic supplementation with orotic acid and magnesium orotate. Cardiovasc Drugs Ther. 1998;12(Suppl 2):147-52.
4. Durlach J, Collery P. Magnesium and potassium in diabetes and carbohydrate metabolism. Review of the present status and recent results. Magnesium. 1984;3(4-6):315-323.
5. Altura BM, Altura BT. Interactions of Mg and K on blood vessels-aspects in view of hypertension. Review of present status and new findings. Magnesium. 1984;3(4-6):175-94.
6. Glick JL. Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer’s disease. Med Hypotheses. 1990;31:211-225.
7. Rude RK, Kirchen ME, Gruber HE, Meyer MH, Luck JS, Crawford DL. Magnesium deficiency-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption. Magnes Res. 1999;12(4):257-67.
8. Swain R, Kaplan-Machlis B. Magnesium for the next millennium. South Med J. 1999;92(11):1040-7.
9. Villanyi P, Votin J, Rahlfs V. Arteriosclerosis, myocardial infarct and blood lipids, their therapeutic modification by magnesium orotate [in German]. Wien Med Wochenschr. 1970;120(5):76-83.
10. Jellinek H, Takacs E. Morphological aspects of the effects of orotic acid and magnesium orotate on hypercholesterolaemia in rabbits. Arzneimittelforschung. 1995;45(8):836-42.
11. Nieper HA. Capillarographic criteria on the effect of magnesium orotate, EPL substances and clofibrate on the elasticity of blood vessels. Agressologie. 1974;15(1):73-7. Available as article #CM19 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
12. Nieper HA. Lowering of incidence of infarction by means of magnesium orotate and potassium orotate in combination with bromelain [in German; unpublished ms., 1977]. Cited in: Heart disease treated with orotates and bromelain. Available as article #CM17 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
13. Golf SW, Bender S, Gruttner J. On the significance of magnesium in extreme physical stress. Cardiovasc Drugs Ther. 1998;12(Suppl 2):197-202.
14. Weller E, Bachert P, Meinck HM, Friedmann B, Bartsch P, Mairbaurl H. Lack of effect of oral Mg-supplementation on Mg in serum, blood cells, and calf muscle. Med Sci Sports Exerc. 1998;30(11):1584-91.
15. Franse LV, Pahor M, Di Bari M, Somes GW, Cushman WC, Applegate WB. Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. Hypertension. 2000;35(5):1025-30. [Full text] [PDF (110 KB)]
16. Norbiato G, Bevilacqua M, Meroni R, et al. Effects of potassium supplementation on insulin binding and insulin action in human obesity: protein-modified fast and refeeding. Eur J Clin Invest. 1984;14(6):414-9.
17. Rubenowitz E, Landin K, Wilhelmsen L. Skeletal muscle magnesium and potassium by gender and hypertensive status. Scand J Clin Lab Invest. 1998;58(1):47-54.
18. Weber CE. Potassium in the etiology of rheumatoid arthritis and heart infarction. J Appl Nutr. 1974;26(1-2):41-67.
19. Nieper HA. The anti-inflammatory and immune-inhibiting effects of calcium orotate on bradytrophic tissues. Agressologie. 1969;10(4):349-57. Available as article #CM14 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
20. Bajusz E. Interrelationships between reparative processes in myocardium and the development of congestive heart failure. Rev Can Biol. 1968;27(1):45-60.
21. Tomov L, Kaloianova A. Changes in hemodynamics in acute myocardial infarct following administration of potassium orotate [in Bulgarian]. Vutr Boles. 1976;15(4):79-82.
22. Kolokol’chikova EG, Pal’tsyn AA. Electron-radioautographic study of the effect of potassium orotate on RNA and protein synthesis in fibroblasts during experimental wound healing [in Russian]. Biull Eksp Biol Med. 1983;96(8):115-8.
23. Bilich GL, Nazarova LV, Sungurova EV. The enzymatic status of circulating lymphocytes as an index of the regenerative process in the lungs under stimulation with pyrimidine and purine derivatives. A clinical experimental study. Haematologia (Budap). 1982;15(1):71-81.
24. Kuzdenbaeva RS, Kurakina VE, Iztleuov MK. Effect of anabolic substances on the state of the individual components of the glutathione-ascorbic acid system [in Russian]. Farmakol Toksikol. 1980;43(5):607-9.
25. Karkishchenko NN, Khaitin MI. Comparative study of the indices of the antidepressive activity of potassium orotate and piracetam [in Russian]. Farmakol Toksikol. 1985;48(2):32-5.
26. Karkishchenko NN, Khaitin MI. Quantitative evaluation of the anxiolytic and nootropic effects of potassium orotate in a wide range of doses [in Russian]. Farmakol Toksikol. 1986;49(1):14-6.
27. Dziedzicka-Wasylewska M, Mackowiak M, Fijat K, Wedzony K. Adaptive changes in the rat dopaminergic transmission following repeated lithium administration. J Neural Transm Gen Sect. 1996;103(7):765-76.
28. Perez-Cruet J, Tagliamonte A, Tagliamonte P, Gessa GL. Stimulation of serotonin synthesis by lithium. J Pharmacol Exp Ther. 1971;178(2):325-30.
29. Rybakowski JK. Antiviral and immunomodulatory effect of lithium. Pharmacopsychiatry. 2000;33(5):159-64.
30. Cernescu C, Popescu L, Constantinescu S, Cernescu S. Antiviral effect of lithium chloride. Virologie. 1988;39(2):93-101.
31. Lieb J. Lithium and immune function. Med Hypotheses. 1987;23(1):73-93.
32. Tabata I, Schluter J, Gulve EA, Holloszy JO. Lithium increases susceptibility of muscle glucose transport to stimulation by various agents. Diabetes. 1994;43(7):903-7.
33. Hu M, Wu H, Chao C. Assisting effects of lithium on hypoglycemic treatment in patients with diabetes. Biol Trace Elem Res. 1997;60(1-2):131-7.
34. Nieper HA. The clinical applications of lithium orotate. A two years study. Agressologie. 1973;14(6):407-11. Available as article #CM12 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
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39. Mocchegiani E, Giacconi R, Muzzioli M, Cipriano C. Zinc, infections and immunosenescence. Mech Ageing Dev. 2000;121(1-3):21-35.
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Resveratrol Found to Improve Health, but Not Longevity in Aging Mice

Resveratrol Found to Improve Health, but Not Longevity in Aging Mice


Scientists have found that the compound resveratrol slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age. This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of overweight, aged mice. The report confirms previous results suggesting the compound, found naturally in foods like grapes and nuts, may mimic, in mice, some of the effects of dietary or calorie restriction, the most effective and reproducible way found to date to alleviate age-associated disease in mammals.

The findings, published July 3, 2008, in Cell Metabolism, may increase interest in resveratrol as a possible intervention for age-related declines, said NIA scientists. The authors emphasized, however, that their findings are based on research in mice, not in humans, and have no immediate and direct application to people, whose health is influenced by a variety of factors beyond those which may be represented in the animal models.

The study is a collaborative effort between the laboratories of Rafael de Cabo, Ph.D., of the Laboratory of Experimental Gerontology at the NIA; David A. Sinclair, Ph.D., of the Glenn Laboratories for Molecular Biology of Aging at Harvard Medical School; and an international group of researchers. The investigators compared mice fed a standard diet, a high-calorie diet, or an every-other-day feeding regimen with or without high- or low-dose resveratrol to study the impact of resveratrol on aging and health. In previous studies, different forms of dietary restriction, including every-other-day feeding, have been shown to improve markers of health.

"Research is attempting to understand the process of aging and to determine how interventions can influence this process. Dietary restriction has well-documented health benefits in mammals, and the study of possible mimetics of it, such as resveratrol, are of great interest," said NIA Director Richard J. Hodes, M.D. "Resveratrol has produced significant effects in animal models, now including mice, where it mimics some, but not all, consequences of caloric restriction. Its effects in humans remain to be studied."

A major finding of the study reported today is that resveratrol prevented age-related and obesity-related cardiovascular functional decline in the mice as determined by several parameters. Total cholesterol was significantly reduced in 22-month-old non-obese mice after 10 months of resveratrol treatment, although triglyceride levels had only a slight, non-significant trend toward a decrease. Further, the aortas of 18-month-old obese and non-obese mice treated with resveratrol functioned significantly better than untreated mice. Resveratrol also moderated inflammation in the heart.

In addition to cardiovascular function, the scientists found resveratrol to have a variety of positive effects on other age-related problems in mice:

  • Treated mice tended to have better bone health, as measured by thickness, volume, mineral content and density, and bending stiffness compared to the non-treated control group.
  • At 30 months of age, resveratrol-treated mice were found to have reduced cataract formation, a condition found to increase with age in control-group mice.
  • Resveratrol enhanced balance and motor coordination in aged animals. Scientists found significant improvement in performance at 21 and 24 months versus 15 months in the resveratrol-treated mice but not in the untreated mice.
  • Resveratrol partially mimicked the effects of dietary restriction on the gene expression profiles of liver, skeletal muscle and adipose (fatty) tissue in mice.


Along with determining the effect of resveratrol on the health of mice, scientists also studied the effect of resveratrol on longevity.

"We found that while quality of life improved with resveratrol, the compound did not significantly affect overall survival or maximum lifespan for mice on a standard diet, compared to mice on the same diet without resveratrol," said de Cabo.

Resveratrol did not have a significant effect on lifespan in animals fed standard chow, suggesting that the intervention did not affect all aspects of the basic aging process. Mice on a high-calorie diet without resveratrol lived the shortest length of time and mice on an every-other-day regimen lived the longest, regardless of resveratrol treatment. However, for mice on a high-calorie diet, mean and maximum lifespan increased for mice on resveratrol when compared with the control mice. Researchers found that resveratrol’s effects on longevity could be completely uncoupled from changes in body weight, meaning that mice on a high-calorie diet with resveratrol did not necessarily lose weight but did experience a longer (and healthier) life than mice on the same high-calorie diet not taking resveratrol. They speculate that improved cardiovascular health and reduced fatty changes in the liver may have contributed to the increased lifespan of resveratrol-treated mice.

Researchers still have much to learn before resveratrol can be recommended for human use. Basic questions of safety and biological effect in humans remain to be studied experimentally.

"We are learning a great deal about how resveratrol affects the health and survival of mammals," said Sinclair. "Continued study of calorie restriction mimetics such as resveratrol may eventually point the way to new medicines to treat diseases of aging."

The NIA leads the federal government effort conducting and supporting research on the biomedical and social and behavioral aspects of aging and the problems of older people. For more information on healthy aging, aging-related research and the NIA, please visit the Institute’s website at www.nia.nih.gov.

The National Institutes of Health (NIH) - The Nation’s Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

Be well,
Medicine-Plants


Health Disclaimer! The information presented on this site should not be construed as personal medical advice or instruction. You should consult appropriate health professionals on any matter relating to your health and well-being. The information and opinions provided here are believed to be accurate and sound, based on the best judgment available to the authors, but readers who fail to consult appropriate health authorities assume the risk of any injuries. The publisher is not responsible for errors or omissions.

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Be well,
Medicine-Plants


Health Disclaimer! The information presented on this site should not be construed as personal medical advice or instruction. You should consult appropriate health professionals on any matter relating to your health and well-being. The information and opinions provided here are believed to be accurate and sound, based on the best judgment available to the authors, but readers who fail to consult appropriate health authorities assume the risk of any injuries. The publisher is not responsible for errors or omissions.

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Are Your Health Problems Yeast Connected?

Some women using MACA750™ experience a “die-off” of candida or yeast cells which causes temporary gastrointestinal changes such as loose stools. Some of these women write to us saying that they never knew they had a yeast infection. Alternative practitioners can test blood samples for candida infection but the simple screening test below can help you decide if candida is a health issue you need to address.

If your answer is “yes” to any question, circle the number in the right hand column. When you’ve completed the questionnaire, add up the points. Your score will help you determine the possibility (or probability) that your health problems are yeast related.

Answer YES or NO and Add Up Your Score
1. Have you taken repeated or prolonged courses of antibacterial drugs?
Yes-4 / No-0 
2. Have you been bothered by recurrent vaginal, prostate or urinary tract infections?
Yes-3 / No-0 
3. Do you feel “sick all over,” yet the cause hasn’t been found?
Yes-2 / No-0 
4. Are you bothered by hormone disturbances, including PMS, menstrual irregularities, sexual dysfunction, sugar craving, low body temperature or fatigue?
Yes-2 / N-0 
5. Are you unusually sensitive to tobacco smoke, perfumes, colognes and other chemical odors?
Yes-2 / No-0 
6. Are you bothered by memory or concentration problems? Do you sometimes feel “spaced out”?
Yes-2 / No-0 
7. Have you taken prolonged courses of Prednisone or other steroids; or have you taken “the pill” for more than 3 years?
Yes-2 / No-0 
8. Do some foods disagree with you or trigger your symptoms?
Yes-1 / No-0 
9. Do you suffer with constipation, diarrhea, bloating or abdominal pain?
Yes-1 / No-0 
10. Does your skin itch, tingle or burn; or is it unusually dry; or are you bothered by rashes?
Yes-1/ No-0 

Scoring for women: If your score is 9 or more, your health problems are probably yeast-connected. If your score is 12 or more, your health problems are almost certainly yeast-connected.

Scoring for men: If your score is 7 or more, your health problems are probably yeast-connected. If your score is 10 or more, your health problems are almost certainly yeast-connected.

Be well,
Medicine-Plants


Health Disclaimer! The information presented on this site should not be construed as personal medical advice or instruction. You should consult appropriate health professionals on any matter relating to your health and well-being. The information and opinions provided here are believed to be accurate and sound, based on the best judgment available to the authors, but readers who fail to consult appropriate health authorities assume the risk of any injuries. The publisher is not responsible for errors or omissions.